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KMID : 0366919980100010245
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Sungkyun Pharmceutical Journal
1998 Volume.10 No. 1 p.245 ~ p.253
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Subacute Oral Toxicity of DWP-311 in Sprague-Dawley Rats
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Abstract
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The subacute oral toxicity study of DWP-311 was carried out in Sprague-Dawley rats of both sexes. We daily examined clinical signs, body weights, hematological and biochemical parameters, and histopathological examinations for 30 days after administration of DWP-311 with different dose levels (0, 0.04, 0.2, and 1.0 g/㎏). There were no clinical signs and pathological changes compared with control group except slight decreases in spontaneous motor activities and locomotions at high dose group of DWP-311. Body weights were not significantly changed in animals treated with DWP-311. In histopathological examinations, there were 2 cases of pneumonia in control group for one male and one female, but it was not directly related to DWP-311. These results indicate that subacute oral toxicities of DWP-311 were low and the no-observed adverse effect level(NOAEL) was considered to be 1.0 g/㎏ in rats.
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